MHC class I transactivator NLRC5 in host immunity, cancer and beyond
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The presentation of antigenic peptides by major histocompatibility complex (MHC) class I and class II molecules is crucial for activation of the adaptive immune system. The nucleotide-binding domain and leucine-rich repeat receptor family members CIITA and NLRC5 function as the major transcriptional activators of MHC class II and class I gene expression, respectively. Since the identification of NLRC5 as the master regulator of MHC class I and class-I-related genes, there have been major advances in understanding the function of NLRC5 in infectious diseases and cancer. Here, we discuss the biological significance and mechanism of NLRC5-dependent MHC class I expression.
author list (cited authors)
Cho, S. X., Vijayan, S., Yoo, J., Watanabe, T., Ouda, R., An, N., & Kobayashi, K. S.