MHC class I transactivator NLRC5 in host immunity, cancer and beyond Academic Article uri icon


  • The presentation of antigenic peptides by major histocompatibility complex (MHC) class I and class II molecules is crucial for activation of the adaptive immune system. The nucleotide-binding domain and leucine-rich repeat receptor family members CIITA and NLRC5 function as the major transcriptional activators of MHC class II and class I gene expression, respectively. Since the identification of NLRC5 as the master regulator of MHC class I and class-I-related genes, there have been major advances in understanding the function of NLRC5 in infectious diseases and cancer. Here, we discuss the biological significance and mechanism of NLRC5-dependent MHC class I expression.

altmetric score

  • 0.5

author list (cited authors)

  • Cho, S. X., Vijayan, S., Yoo, J., Watanabe, T., Ouda, R., An, N., & Kobayashi, K. S.

citation count

  • 1

publication date

  • August 2020