Toxicity and mutagenicity of hymenoxon, a sequiterpene lactone Academic Article uri icon

abstract

  • The oral LD50 of hymenoxon in Swiss white mice was found to be 241 +/- 37 mg/kg. No significant sex differences were observed. Pretreatment of male mice for 3 days using doses of 50 and 100 mg/kg hymenoxon failed to alter significantly pentobarbital sleeping time. Hymenoxon was found to be a direct-acting mutagen in the Salmonella/mammalian microsome test. Urine samples obtained from hymenoxon-treated mice were found to be negative activity when tested directly and when incubated with beta-glucuronidase. Hymenoxon did not produce lethal DNA damage as measured in the Escherichia coli polA or Bacillus subtilis recombinational assays.

author list (cited authors)

  • Jones, D. H., & Kim, H. L.

citation count

  • 5

complete list of authors

  • Jones, DH||Kim, HL

publication date

  • December 1981