Toxicity and mutagenicity of hymenoxon, sequiterpene lactone. Academic Article

abstract

• The oral LD50 of hymenoxon in Swiss white mice was found to be 241 +/- 37 mg/kg. No significant sex differences were observed. Pretreatment of male mice for 3 days using doses of 50 and 100 mg/kg hymenoxon failed to alter significantly pentobarbital sleeping time. Hymenoxon was found to be a direct-acting mutagen in the Salmonella/mammalian microsome test. Urine samples obtained from hymenoxon-treated mice were found to be negative activity when tested directly and when incubated with beta-glucuronidase. Hymenoxon did not produce lethal DNA damage as measured in the Escherichia coli polA or Bacillus subtilis recombinational assays.

authors

• Jones, Daniel

published proceedings

• Toxicol Lett

author list (cited authors)

• Jones, D. H., & Kim, H. L.

citation count

• 6

complete list of authors

• Jones, DH||Kim, HL

publication date

• January 1981

publisher

• Elsevier  Publisher

published in

• Toxicology Letters  Journal

keywords

• Animals
• DNA, Bacterial
• Female
• Lethal Dose 50
• Male
• Mice
• Mutagenicity Tests
• Mutagens
• Pentobarbital
• Plants, Toxic
• Sesquiterpenes
• Sleep

PubMed Central ID

• 7330900

Digital Object Identifier (DOI)

• 10.1016/0378-4274(81)90016-3

start page

• 395

end page

• 401

volume

• 9

issue

• 4

URL

• http://dx.doi.org/10.1016/0378-4274(81)90016-3