Sarcolemmal dependence of isosorbide dinitrate-induced relaxation of aortic smooth muscle. Academic Article

abstract

• Studies were conducted to determine if ISDN antagonizes the contractile responses to calcium of chemically-skinned aortic smooth muscle preparations. Isosorbide dinitrate relaxed intact aortic smooth muscle segments in a dose-dependent manner (0.01-100 microM). At all concentrations tested, ISDN was unable to relax triton-skinned smooth muscle preparations. However, the tension development of skinned preparations was inhibited by trifluoperazine (10 microM), a calmodulin antagonist. These results suggest that the relaxation of intact aortic smooth muscle preparations induced by ISDN is not related to an interference with calmodulin-dependent contractile events.

authors

• Ramos, Kenneth

published proceedings

• Res Commun Chem Pathol Pharmacol

author list (cited authors)

• Ramos, K.

citation count

• 3

complete list of authors

• Ramos, K

publication date

• May 1986

published in

• Research communications in chemical pathology and pharmacology  Journal

keywords

• Animals
• Aorta, Thoracic
• Calcium
• Guinea Pigs
• In Vitro Techniques
• Isosorbide Dinitrate
• Male
• Muscle, Smooth, Vascular
• Sarcolemma
• Trifluoperazine
• Vasoconstriction
• Vasodilation

PubMed Central ID

• 3715199

start page

• 195

end page

• 205

volume

• 52

issue

• 2