Genetic and molecular mechanisms of chemical atherogenesis. Academic Article

abstract

• Injury to the cellular components of the vascular wall and blood by endogenous and exogenous chemicals has been associated with atherosclerosis in humans and experimental systems. The genetic and molecular mechanisms responsible for initiation and promotion of atherosclerotic changes include modulation of extracellular matrix-integrin axis, genes involved in the regulation of growth and differentiation and possibly, genomic stability. This review summarizes seminal studies over the past 20 years that shed light on critical gene-gene and gene-environment interactions mediating the atherogenic response to chemical injury.

authors

• Ramos, Kenneth

published proceedings

• Mutat Res

author list (cited authors)

• Ramos, K. S., Partridge, C. R., & Teneng, I.

citation count

• 14

complete list of authors

• Ramos, Kenneth S||Partridge, Charles R||Teneng, Ivo

publication date

• August 2007

publisher

• Elsevier  Publisher

published in

• MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS  Journal

keywords

• Animals
• Atherosclerosis
• Endothelium, Vascular
• Humans
• Oxidative Stress
• Reactive Oxygen Species

PubMed Central ID

• 17433375

Digital Object Identifier (DOI)

• 10.1016/j.mrfmmm.2006.12.009

start page

• 18

end page

• 30

volume

• 621

issue

• 1-2

URL

• http://dx.doi.org/10.1016/j.mrfmmm.2006.12.009