L1 retrotransposon and retinoblastoma: molecular linkages between epigenetics and cancer. Academic Article

abstract

• Long interspersed nuclear elements (LINEs) are mobile sequences shown to play a fundamental role in eukaryotic genome evolution. Recently, increasing interest has been directed at unveiling molecular mechanisms by which LINE-1 (L1), a ubiquitous member of this family, regulates gene expression and mammalian cell development, differentiation, and cancer. This mini review summarizes recent studies conducted to examine stress-induced L1 reactivation, with special attention given to the role of E2F/Rb transcription factors in epigenetic silencing of L1 and its potential role as a global modifier of chromatin structure and function. The last section focuses on the impact of histone deacetylase inhibitors in the regulation of gene function, chromatin structure, and cancer treatment through alterations in epigenetic signaling.

authors

• Ramos, Kenneth

published proceedings

• Curr Mol Med

author list (cited authors)

• Montoya-Durango, D. E., & Ramos, K. S.

citation count

• 14

complete list of authors

• Montoya-Durango, DE||Ramos, KS

publication date

• July 2010

publisher

• BENTHAM SCIENCE PUBLISHERS  Publisher

published in

• Current Molecular Medicine  Journal

keywords

• Animals
• Base Sequence
• Epigenesis, Genetic
• Humans
• Long Interspersed Nucleotide Elements
• Molecular Sequence Data
• Retinoblastoma
• Retroelements

PubMed Central ID

• 20540701

Digital Object Identifier (DOI)

• 10.2174/156652410791608234

start page

• 511

end page

• 521

volume

• 10

issue

• 5

URL

• http://dx.doi.org/10.2174/156652410791608234