Conditioned taste aversion and unconditioned suppression of water intake induced by phenylpropanolamine in rats Academic Article uri icon


  • The putative aversive properties of phenylpropanolamine (PPA), an analog of amphetamine, were delineated in two behavioral tests. In a conditioned taste aversion paradigm, PPA (10, 20, or 40 mg/kg) was found to induce dose-dependent taste aversion, whereas identical dosages of PPA were found to produce dose-dependent unconditioned suppression of water intake in 23.5-h water-deprived rats. Comparison of the dose-response curves for the aversion and hypodipsia induced by PPA indicates that a single process, presumably malaise or toxicosis, may mediate these effects. These findings question the notion that PPA induces anorexia via activation of a CNS satiety mechanism and lend credence to the suggestion advanced herein that nonspecific malaise may mediate the moderate anorectic activity of PPA observed in rodents and humans. 1981, Psychonomic Society, Inc.. All rights reserved.

published proceedings

  • Physiological Psychology

author list (cited authors)

  • Wellman, P. J., Malpas, P. B., & Wikler, K. C.

citation count

  • 13

complete list of authors

  • Wellman, Paul J||Malpas, Phillis B||Wikler, Kenneth C

publication date

  • June 1981