Conditioned taste aversion and unconditioned suppression of water intake induced by phenylpropanolamine in rats Academic Article uri icon


  • The putative aversive properties of phenylpropanolamine (PPA), an analog of amphetamine, were delineated in two behavioral tests. In a conditioned taste aversion paradigm, PPA (10, 20, or 40 mg/kg) was found to induce dose-dependent taste aversion, whereas identical dosages of PPA were found to produce dose-dependent unconditioned suppression of water intake in 23.5-h water-deprived rats. Comparison of the dose-response curves for the aversion and hypodipsia induced by PPA indicates that a single process, presumably malaise or toxicosis, may mediate these effects. These findings question the notion that PPA induces anorexia via activation of a CNS satiety mechanism and lend credence to the suggestion advanced herein that nonspecific malaise may mediate the moderate anorectic activity of PPA observed in rodents and humans. © 1981, Psychonomic Society, Inc.. All rights reserved.

author list (cited authors)

  • Wellman, P. J., Malpas, P. B., & Wikler, K. C.

citation count

  • 13

publication date

  • June 1981