Effects of dorsolateral tegmental lesions on amphetamine- and lithium-induced taste aversions.
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abstract
Female rats with lesions of the dorsolateral tegmentum (DLT) displayed both hyperphagia and attenuation of the conditioned taste aversion induced by amphetamine (2.0 mg/kg). DLT lesions, however, did not influence conditioned taste aversion induced by lithium chloride (0.15 M). These outcomes complement recent observations of attenuated lithium, but not amphetamine, taste aversion following destruction of the area postrema. It is suggested that the ventral nonadrenergic bundle, at the level of the dorsolateral tegmentum, may mediate the aversive properties of amphetamine. 1981.