Decreased intake of a liquid diet in nonfood-deprived rats following intra-PVN injections of GLP-1 (7-36) amide. Conference Paper

abstract

• I.c.v. administration of glucagon-like peptide-1 (7-36) amide (GLP-1) dose dependently suppresses food intake in rats, and induces activation of c-fos within rat paraventricular hypothalamus (PVN). The present study sought to determine whether GLP-1 (7-36) amide may act within the PVN by examining the effects of intra-PVN administration of GLP-1 (7-36) amide on food intake in rats. Adult male rats (n = 11) were prepared with indwelling guide cannulae aimed at the PVN. Rats were allowed access to a palatable liquid diet (Ensure) and water during a daily 60-min test period with intakes measured every 15 min. Intra-PVN administration of GLP-1 (7-36) amide (10, 50, 100 and 200 ng) did not alter latency to feed, but did suppress liquid diet intake over a 1-h testing period, as a function of dose. These results suggest that GLP-1 (7-36) amide may act, in part, to suppress feeding through interactions with cells within the PVN.

authors

• Wellman, Paul

published proceedings

• Pharmacol Biochem Behav

author list (cited authors)

• McMahon, L. R., & Wellman, P. J.

citation count

• 36

complete list of authors

• McMahon, LR||Wellman, PJ

publication date

• January 1997

publisher

• Elsevier  Publisher

published in

• Pharmacology, Biochemistry and Behavior  Journal

keywords

• Adrenergic Alpha-Agonists
• Animals
• Depression, Chemical
• Diet
• Eating
• Glucagon
• Glucagon-Like Peptide 1
• Glucagon-Like Peptides
• Male
• Microinjections
• Neurotransmitter Agents
• Norepinephrine
• Paraventricular Hypothalamic Nucleus
• Peptide Fragments
• Rats
• Rats, Sprague-Dawley

PubMed Central ID

• 9329057

Digital Object Identifier (DOI)

• 10.1016/s0091-3057(97)90017-4

start page

• 673

end page

• 677

volume

• 58

issue

• 3

URL

• http://dx.doi.org/10.1016/s0091-3057(97)90017-4