Effects of paraventricular hypothalamic microinjections of phenylpropanolamine and d-amphetamine on mash intake in rats. Academic Article

abstract

• The present experiment compared the effects of unilateral microinjections (40, 80 and 160 nmol/0.5 microliter) of phenylpropanolamine (PPA: d,l-norephedrine) and d-amphetamine sulfate within the paraventricular hypothalamus (PVN) on consumption of a palatable sweetened-mash diet in 15-hour food-deprived adult male rats. Intracranial microinjections were administered 5 minutes prior to each 30-minute feeding trial. PPA, at a dose of 160 nmol, suppressed feeding by 42%, whereas a similar dose of amphetamine suppressed feeding by 49%. Amphetamine or PPA doses of 40 and 80 nmol were without significant effect on feeding behavior. A relatively high dose of 160 nmol amphetamine was required to suppress feeding after injection into the PVN whereas much lower amphetamine concentrations are required to suppress feeding after injection into the perifornical hypothalamus. In contrast, PPA has some anorexic activity within the PVN but not within the perifornical hypothalamus.

authors

• Wellman, Paul

published proceedings

• Brain Res Bull

author list (cited authors)

• Wellman, P. J., & Davies, B. T.

citation count

• 22

complete list of authors

• Wellman, PJ||Davies, BT

publication date

• January 1990

publisher

• Elsevier  Publisher

published in

• Brain Research Bulletin  Journal

keywords

• Animals
• Dextroamphetamine
• Diet
• Feeding Behavior
• Food Deprivation
• Male
• Microinjections
• Paraventricular Hypothalamic Nucleus
• Phenylpropanolamine
• Rats
• Rats, Inbred Strains
• Stereotaxic Techniques

Digital Object Identifier (DOI)

• 10.1016/0361-9230(90)90079-f

start page

• 335

end page

• 338

volume

• 25

issue

• 2

URL

• http://dx.doi.org/10.1016/0361-9230(90)90079-f