Comparison of brown adipose tissue thermogenesis induced by congeners and isomers of phenylpropanolamine. Academic Article

abstract

• The present experiment compared the effects of intraperitoneal injection (.0223 mMol/kg) of several phenethylamine congeners and isomers including amphetamine (AMP), ephedrine (EPH), methoxyphenamine (MET), norpseudoephedrine (NOR), pseudoephedrine (PS) and phenylpropanolamine (PPA) on in vivo interscapular brown adipose tissue temperature in adult male rats. Comparisons of isomer potency revealed that the 1-isomer was more thermogenic than the d-isomer for EPH and PPA but not for AMP, NOR and PS. Congener potency order was: AMP greater than PPA greater than EPH greater than NOR = MET greater than PS. The implications of these data for the weight-reducing activity of these compounds is discussed.

authors

• Wellman, Paul

published proceedings

• Life Sci

author list (cited authors)

• Wellman, P. J., & Marmon, M. M.

citation count

• 8

complete list of authors

• Wellman, PJ||Marmon, MM

publication date

• January 1985

publisher

• Elsevier  Publisher

published in

• LIFE SCIENCES  Journal

keywords

• Adipose Tissue, Brown
• Animals
• Body Temperature Regulation
• Isomerism
• Male
• Phenethylamines
• Phenylpropanolamine
• Rats
• Rats, Inbred Strains
• Structure-Activity Relationship

Digital Object Identifier (DOI)

• 10.1016/0024-3205(85)90591-0

start page

• 1023

end page

• 1028

volume

• 37

issue

• 11

URL

• http://dx.doi.org/10.1016/0024-3205(85)90591-0