Effects of haloperidol on anorexia induced by l-norephedrine and d-amphetamine in adult rats.
Academic Article
Overview
Research
Identity
Additional Document Info
Other
View All
Overview
abstract
Although amphetamine anorexia has been linked to activation of dopaminergic receptors within the lateral aspects of the hypothalamus, the receptor type by which phenylpropanolamine (PPA: the racemic mixture of d- and l-norephedrine) induces anorexia has not been identified. In the present experiment, separate groups of adult male rats were pretreated (IP) with either 0.9% saline or haloperidol (either 0.4 or 0.8 mg/kg) 45 minutes prior to treatment (IP) with either saline or 20 mg/kg l-NEP (the active enantiomer of PPA) and were then allowed 180 minutes access to food and water. Treatment with 20 mg/kg l-NEP induced comparable reductions in food intake of approximately 30% in rats pretreated with either dose of haloperidol or saline. In a sub-experiment, it was demonstrated that 1.0 mg/kg d-amphetamine sulfate reduced food intake by 25%, but this anorexic action was completely attenuated by 0.8 mg/kg haloperidol given 45 minutes prior to feeding. These results add to a growing body of literature that documents important differences between the mechanisms by which amphetamine and PPA produce their anorexic actions.