Isobolographic assessment of the effects of combinations of phenylpropanolamine and fenfluramine on food intake in rats. Academic Article uri icon

abstract

  • Phenylpropanolamine (PPA) suppresses appetite in rats via activation of alpha 1-adrenergic receptors within the paraventricular hypothalamus (PVN). The serotonergic (5-HT) agonist fenfluramine (FEN) is thought to suppress appetite via stimulation of 5-HT release within the PVN rather than activation of adrenergic receptors. Whether a mixture of these neurochemically distinct anorexic drugs will serve as an effective appetite suppressant is unknown. In the present experiment, drug-drug interactions between PPA and FEN were explored using an isobologram technique. Fixed doses of PPA (0 vs. 5 mg/kg) were combined with various doses of FEN (1.25, 2.5, and 5.0 mg/kg) and fixed doses of FEN (0 vs. 2.5 mg/kg) were combined with various doses of PPA (0, 5, 10, and 15 mg/kg). Drug combinations were injected IP 30 min before a 1-h feeding trial in 16-h food-deprived rats. PPA and FEN were dose-additive in this paradigm, an outcome that supports the feasibility of a new appetite suppressant composed of a mixture of PPA and FEN.

published proceedings

  • Pharmacol Biochem Behav

author list (cited authors)

  • Wellman, P. J., Tow, S., & McMahon, L.

citation count

  • 10

complete list of authors

  • Wellman, PJ||Tow, S||McMahon, L

publication date

  • February 1995