Effects of amphetamine and phenylpropanolamine on food intake in rats with ventromedial hypothalamic or dorsolateral tegmental damage. Academic Article

abstract

• Female rats with sham lesions or lesions of the ventromedial hypothalamus (VMH) or the dorsolateral tegmentum (DLT) were maintained at 80% normal body weight to minimize possible group differences in hunger motivation. VMH rats displayed attenuated amphetamine (0.5, 1.0, and 2.0 mg/kg) anorexia when fed a high-fat test diet but normal anorexia when fed a pellet test diet whereas DLT rats displayed attenuated amphetamine anorexia when fed either test diet. Neither VMH nor DLT rats displayed attenuated anorexia to phenylpropanolamine (5.0, 10.0, and 20.0 mg/kg), an analogue of amphetamine. These results are discussed in terms of an amphetamine-activated arousal mechanism within the DLT. 1980, All rights reserved.

authors

• Wellman, Paul

published proceedings

• Physiol Behav

author list (cited authors)

• Wellman, P. J., & Peters, R. H.

citation count

• 21

complete list of authors

• Wellman, PJ||Peters, RH

publication date

• January 1980

publisher

• Elsevier  Publisher

published in

• Physiology and Behavior  Journal

keywords

• Animals
• Body Weight
• Dextroamphetamine
• Diet
• Dietary Fats
• Feeding Behavior
• Female
• Hypothalamus
• Phenylpropanolamine
• Rats
• Tegmentum Mesencephali

Digital Object Identifier (DOI)

• 10.1016/0031-9384(80)90300-5

start page

• 819

end page

• 827

volume

• 25

issue

• 6

URL

• http://dx.doi.org/10.1016/0031-9384(80)90300-5