Effects of amphetamine and phenylpropanolamine on food intake in rats with ventromedial hypothalamic or dorsolateral tegmental damage Academic Article uri icon

abstract

  • Female rats with sham lesions or lesions of the ventromedial hypothalamus (VMH) or the dorsolateral tegmentum (DLT) were maintained at 80% normal body weight to minimize possible group differences in hunger motivation. VMH rats displayed attenuated amphetamine (0.5, 1.0, and 2.0 mg/kg) anorexia when fed a high-fat test diet but normal anorexia when fed a pellet test diet whereas DLT rats displayed attenuated amphetamine anorexia when fed either test diet. Neither VMH nor DLT rats displayed attenuated anorexia to phenylpropanolamine (5.0, 10.0, and 20.0 mg/kg), an analogue of amphetamine. These results are discussed in terms of an amphetamine-activated arousal mechanism within the DLT. © 1980, All rights reserved.

author list (cited authors)

  • Wellman, P. J., & Peters, R. H.

citation count

  • 21

publication date

  • December 1980