Effects of guanethidine sympathectomy on feeding, drinking, weight gain and amphetamine anorexia in the rat. Academic Article

abstract

• Adult female rats that underwent sympathectomy induced by guanethidine treatment (10, 20 or 40 mg/kg) exhibited markedly increased water intake, but did not display significant alterations of either food intake, body weight, or the Lee Index of obesity. Guanethidine treatment did not attenuate amphetamine anorexia as evidenced by comparable dose-dependent reductions in food intake to d-amphetamine sulfate (0.25, 0.50, 1.0, and 2.0 mg/kg) in sympathectomized and control rats. These data are not consistent with the hypothesis that amphetamine anorexia is partially mediated via enhanced BAT thermogenesis.

authors

• Wellman, Paul

published proceedings

• Physiol Behav

author list (cited authors)

• Freeman, P. H., Wellman, P. J., & Clark, D. E.

citation count

• 4

complete list of authors

• Freeman, PH||Wellman, PJ||Clark, DE

publication date

• January 1985

publisher

• Elsevier  Publisher

published in

• Physiology and Behavior  Journal

keywords

• Adipose Tissue, Brown
• Animals
• Body Temperature Regulation
• Body Weight
• Dextroamphetamine
• Drinking
• Eating
• Female
• Guanethidine
• Rats
• Sympathectomy, Chemical
• Sympathetic Nervous System

Digital Object Identifier (DOI)

• 10.1016/0031-9384(85)90325-7

start page

• 473

end page

• 477

volume

• 35

issue

• 3

URL

• http://dx.doi.org/10.1016/0031-9384(85)90325-7