Weight loss induced by chronic phenylpropanolamine: anorexia and brown adipose tissue thermogenesis. Academic Article uri icon

abstract

  • The effects of chronic treatment with phenylpropanolamine (PPA) on body weight (BW), food intake (FI), and water intake (WI) and interscapular brown adipose tissue (IBAT) thermogenesis in adult male Sprague-Dawley rats were evaluated in 2 experiments. In Experiment 1, rats were treated (IP) twice daily (0900 and 2100 hr) for 12 days with either saline or 5, 10, or 20 mg/kg dl-PPA. Rats treated with 20 mg/kg dl-PPA exhibited significant decreases in both FI and BW but not WI. Basal IBAT temperature was slightly increased in chronic 20 mg/kg dl-PPA rats and there was no evidence of tolerance to the acute IBAT thermogenic effect of 20 mg/kg dl-PPA. In Experiment 2, rats were treated twice daily (0900 and 2100 hr) for 12 days with either saline or 20 mg/kg of either d-PPA or l-PPA. There was a 2-fold difference in the potency of these PPA isomers on FI, BW and IBAT thermogenesis. Body composition analyses revealed that l-PPA, but not d-PPA, induced a significant loss of carcass lipid without significant changes in carcass ash, water or protein levels. These data suggest that the weight-reducing action of PPA may reflect a combined effect of this drug on both food intake and BAT thermogenesis.

published proceedings

  • Pharmacol Biochem Behav

author list (cited authors)

  • Wellman, P. J., & Sellers, T. L.

citation count

  • 31

complete list of authors

  • Wellman, PJ||Sellers, TL

publication date

  • March 1986