Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.
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Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribosomal RNAs (rRNAs) and proteins and minicircles bearing guide RNAs (gRNAs) for mRNA editing. All RNAs are produced by a phage-type RNA polymerase as 3' extended precursors, which undergo exonucleolytic trimming. Most pre-mRNAs proceed through 3' adenylation, uridine insertion/deletion editing, and 3' A/U-tailing. The rRNAs and gRNAs are 3' uridylated. Historically, RNA editing has attracted major research effort, and recently essential pre- and postediting processing events have been discovered. Here, we classify the key players that transform primary transcripts into mature molecules and regulate their function and turnover.
author list (cited authors)
Aphasizheva, I., Alfonzo, J., Carnes, J., Cestari, I., Cruz-Reyes, J., Göringer, H. U., ... Aphasizhev, R.
complete list of authors
Aphasizheva, Inna||Alfonzo, Juan||Carnes, Jason||Cestari, Igor||Cruz-Reyes, Jorge||Göringer, H Ulrich||Hajduk, Stephen||Lukeš, Julius||Madison-Antenucci, Susan||Maslov, Dmitri A||McDermott, Suzanne M||Ochsenreiter, Torsten||Read, Laurie K||Salavati, Reza||Schnaufer, Achim||Schneider, André||Simpson, Larry||Stuart, Kenneth||Yurchenko, Vyacheslav||Zhou, Z Hong||Zíková, Alena||Zhang, Liye||Zimmer, Sara||Aphasizhev, Ruslan