Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes. Academic Article uri icon

abstract

  • Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribosomal RNAs (rRNAs) and proteins and minicircles bearing guide RNAs (gRNAs) for mRNA editing. All RNAs are produced by a phage-type RNA polymerase as 3' extended precursors, which undergo exonucleolytic trimming. Most pre-mRNAs proceed through 3' adenylation, uridine insertion/deletion editing, and 3' A/U-tailing. The rRNAs and gRNAs are 3' uridylated. Historically, RNA editing has attracted major research effort, and recently essential pre- and postediting processing events have been discovered. Here, we classify the key players that transform primary transcripts into mature molecules and regulate their function and turnover.

published proceedings

  • Trends Parasitol

altmetric score

  • 6.8

author list (cited authors)

  • Aphasizheva, I., Alfonzo, J., Carnes, J., Cestari, I., Cruz-Reyes, J., Göringer, H. U., ... Aphasizhev, R.

citation count

  • 25

complete list of authors

  • Aphasizheva, Inna||Alfonzo, Juan||Carnes, Jason||Cestari, Igor||Cruz-Reyes, Jorge||Göringer, H Ulrich||Hajduk, Stephen||Lukeš, Julius||Madison-Antenucci, Susan||Maslov, Dmitri A||McDermott, Suzanne M||Ochsenreiter, Torsten||Read, Laurie K||Salavati, Reza||Schnaufer, Achim||Schneider, André||Simpson, Larry||Stuart, Kenneth||Yurchenko, Vyacheslav||Zhou, Z Hong||Zíková, Alena||Zhang, Liye||Zimmer, Sara||Aphasizhev, Ruslan

publication date

  • April 2020