Effects of intra-PVN injections of d- and l-norephedrine on feeding in rats. Academic Article

abstract

• Phenylpropanolamine (PPA) is thought to inhibit feeding by activation of alpha 1-adrenergic receptors within the paraventricular hypothalamus (PVN). Systemic injections of the PPA component enantiomers, d- and l-norephedrine (NEP), result in differential suppression of feeding (l-NEP more potent than d-NEP). Whether the norephedrine racemates induce differential anorexia subsequent to injection into the PVN is unknown. In the present study, adult male rats received intra-PVN injections of the d- and l-norephedrine enantiomers (0, 80, 160, and 240 nmol). Significantly greater anorexia was obtained for l-NEP relative to d-NEP. These results document a stereospecific effect of the norephedrine enantiomers within the PVN in inhibiting food intake and suggest that the interaction of these enantiomers with PVN alpha 1-adrenoceptors may mediate the similar difference in potency noted for systemic injections of d- and l-norephedrine.

authors

• Wellman, Paul

published proceedings

• Brain Res Bull

author list (cited authors)

• Wellman, P. J., DiCarlo, B., Morien, A., & Davies, B. T.

citation count

• 4

complete list of authors

• Wellman, PJ||DiCarlo, B||Morien, A||Davies, BT

publication date

• January 1993

publisher

• Elsevier  Publisher

published in

• Brain Research Bulletin  Journal

keywords

• Animals
• Anorexia
• Dose-Response Relationship, Drug
• Feeding Behavior
• Male
• Microinjections
• Norepinephrine
• Paraventricular Hypothalamic Nucleus
• Rats
• Rats, Sprague-Dawley
• Stereoisomerism

Digital Object Identifier (DOI)

• 10.1016/0361-9230(93)90213-u

start page

• 443

end page

• 445

volume

• 32

issue

• 4

URL

• http://dx.doi.org/10.1016/0361-9230(93)90213-u