Conditioned saccharin taste aversion induced by mycotoxins in rats: lack of effect of ochratoxin A. Academic Article

abstract

• The present study examined the putative aversive action of ochratoxin A (OA) using a conditioned saccharin aversion paradigm. Adult male rats consumed a 0.1% saccharin solution then were treated (IP) with either a 5% NaHCO3 vehicle (negative control), 32 mg/kg LiCl (positive control) or 0.75, 1.5 or 3.0 mg/kg OA. Twenty-four hours later, the rats were given a choice between tap water and the 0.1% saccharin solution. Rats treated with the vehicle or any of the doses of OA exhibited a marked preference for the saccharin solution, whereas the rats treated with LiCl exhibited a marked rejection of the saccharin solution. The implications of these data for an understanding of mycotoxicosis are discussed.

authors

• Wellman, Paul

published proceedings

• Pharmacol Biochem Behav

author list (cited authors)

• Clark, D. E., & Wellman, P. J.

citation count

• 1

complete list of authors

• Clark, DE||Wellman, PJ

publication date

• January 1989

publisher

• Elsevier  Publisher

published in

• Pharmacology, Biochemistry and Behavior  Journal

keywords

• Animals
• Avoidance Learning
• Male
• Mycotoxins
• Ochratoxins
• Rats
• Rats, Inbred Strains
• Saccharin
• Taste

Digital Object Identifier (DOI)

• 10.1016/0091-3057(89)90040-3

start page

• 819

end page

• 821

volume

• 32

issue

• 3

URL

• http://dx.doi.org/10.1016/0091-3057(89)90040-3