A fish oil/pectin diet suppresses radiation-enhanced colon carcinogenesis via down-regulation of the beta-catenin signaling pathway Conference Paper uri icon

abstract

  • In our previous study, a fish oil/pectin (FP) diet protected against radiationenhanced colon carcinogenesis by maintaining an elevated level of apoptosis relative to a corn oil/cellulose (CC) diet. The goal of this study was to determine the differences between the protective and promotive diets in the patterns of gene expression measured in exfoliated colonocytes from rats exposed to radiation (+/ 1 Gy, 1 GeV/nucleon Fe ions) and a chemical carcinogen (AOM, 2x, 15 mg/kg BW). Microarray data were analyzed using a mixed model ANOVA procedure, and genes exhibiting differential expression underwent Gene Ontology (GO) enrichment analyses. Radiation treatment affected expression of genes within the Wnt/catenin pathways, which are involved in cell proliferation and apoptosis. FP feeding reduced expression of tyrosine kinase related genes, which are regulators of the RasPI3K/Akt signaling pathway. Therefore, a FP containing diet may suppress catenin signaling induced by the radiation treatment, thereby contributing to the maintenance of apoptosis.Grant Funding SourceSupported by NSBRI (NASA NCC 958) and NIH (CA57030 and CA59034).

published proceedings

  • FASEB JOURNAL

author list (cited authors)

  • Kim, H., Turner, N. D., Taddeo, S. S., Davidson, L. A., Wang, N., Vannucci, M., ... Lupton, J. R.

citation count

  • 0

complete list of authors

  • Kim, Hyemee||Turner, Nancy D||Taddeo, Stella S||Davidson, Laurie A||Wang, Naisyin||Vannucci, Marina||Chapkin, Robert S||Carroll, Raymond J||Lupton, Joanne R

publication date

  • April 2009

publisher