Nitric Oxide. IV. Determinants of nitric oxide protection and toxicity in liver. Academic Article

abstract

• Whereas nitric oxide (NO) produced by constitutive endothelial NO synthase is protective to the liver, NO produced by the inducible NO synthase (iNOS) can be either toxic or protective depending on the conditions. The availability of selective iNOS inhibitors and mice lacking various NOS isoforms made it possible to begin to elucidate the precise roles of NO in the liver. Under conditions of redox stress, induced NO contributes to hepatic damage. However, in acute inflammatory conditions associated with cytokine exposure, NO acts as a potent inhibitor of apoptosis in the liver. Our current understanding of the mechanisms by which NO exerts both hepatoprotective and hepatotoxic actions is discussed in this themes article.

authors

• Li, Jianrong

published proceedings

• Am J Physiol

author list (cited authors)

• Li, J., & Billiar, T. R.

citation count

• 198

complete list of authors

• Li, J||Billiar, TR

publication date

• May 1999

publisher

• American Physiological Society  Publisher

published in

• AMERICAN JOURNAL OF PHYSIOLOGY  Journal

keywords

• Animals
• Chemical And Drug Induced Liver Injury
• Humans
• Liver
• Mice
• Nitric Oxide
• Nitric Oxide Synthase
• Nitric Oxide Synthase Type II
• Oxidation-Reduction

Digital Object Identifier (DOI)

• 10.1152/ajpgi.1999.276.5.G1069

start page

• G1069

end page

• G1073

volume

• 276

issue

• 5

URL

• http://dx.doi.org/10.1152/ajpgi.1999.276.5.g1069