The anti-apoptotic actions of nitric oxide in hepatocytes. Academic Article uri icon


  • Nitric oxide (NO) has anti-apoptotic actions in hepatocytes in vitro and in vivo. The protection is mediated via the S-nitrosylation of procaspases as well as the active caspase enzymes. NO stimulation of the cGMP/protein kinase G pathway also appears to contribute to the protective effect of NO. Here we review the evidence for the direct inhibition of NO with the apoptotic signaling pathways in hepatocytes.

published proceedings

  • Cell Death Differ

author list (cited authors)

  • Li, J., & Billiar, T. R.

citation count

  • 65

complete list of authors

  • Li, J||Billiar, TR

publication date

  • October 1999