The anti-apoptotic actions of nitric oxide in hepatocytes. Academic Article

abstract

• Nitric oxide (NO) has anti-apoptotic actions in hepatocytes in vitro and in vivo. The protection is mediated via the S-nitrosylation of procaspases as well as the active caspase enzymes. NO stimulation of the cGMP/protein kinase G pathway also appears to contribute to the protective effect of NO. Here we review the evidence for the direct inhibition of NO with the apoptotic signaling pathways in hepatocytes.

authors

• Li, Jianrong

published proceedings

• Cell Death Differ

author list (cited authors)

• Li, J., & Billiar, T. R.

citation count

• 65

complete list of authors

• Li, J||Billiar, TR

publication date

• October 1999

publisher

• Springer Nature  Publisher

published in

• Cell Death and Differentiation  Journal

keywords

• Animals
• Apoptosis
• Cytoprotection
• Liver
• Nitric Oxide

PubMed Central ID

• 10556971

Digital Object Identifier (DOI)

• 10.1038/sj.cdd.4400579

start page

• 952

end page

• 955

volume

• 6

issue

• 10

URL

• http://dx.doi.org/10.1038/sj.cdd.4400579