Metabolomic Salivary Biomarkers for Oral Cancer Detection
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abstract
With advances in cancer detection and treatment, the survival rate for many cancers has greatly improved, but the rate for oral cancer remains low; about 40% of oral cancer patients die within 5 years, usually because it is not diagnosed until already at an advanced stage. Thus, we urgently need to detect oral cancer earlier. Because constituents of human saliva have been found to reflect the body’s physiological state, analyzing saliva holds promise as an easy way to test for oral cancer. Research has identified more than 100 salivary constituents that could help to detect oral cancer. These “potential salivary biomarkers” are constituents that have shown significantly different levels in o... Read More With advances in cancer detection and treatment, the survival rate for many cancers has greatly improved, but the rate for oral cancer remains low; about 40% of oral cancer patients die within 5 years, usually because it is not diagnosed until already at an advanced stage. Thus, we urgently need to detect oral cancer earlier. Because constituents of human saliva have been found to reflect the body’s physiological state, analyzing saliva holds promise as an easy way to test for oral cancer. Research has identified more than 100 salivary constituents that could help to detect oral cancer. These “potential salivary biomarkers” are constituents that have shown significantly different levels in oral cancer patients when compared to levels found in healthy persons. However, many candidate salivary biomarkers have also been found to show significantly different levels in patients with common oral inflammatory diseases--such as gum disease, which affects about 48% of the US population.........
