Can adopting multiple revenue streams secure long-term sustainability of HIEs? Healthcare information exchanges (HIEs) facilitate information sharing among participating healthcare practices. Despite HIEs’ pivotal role in improving healthcare delivery, many struggle to be financially sustainable in the long run. As a practical and implementable solution for this issue, this article proposes a multiperiod two-service model that improves the profitability of HIEs while retaining a sizable member pool. This study provides the guidelines for HIEs in adopting a two-service model. It also sheds light on how policymakers could intervene successfully to improve participation of healthcare providers and operations of the HIEs to guarantee long-term survival.