A high-resolution comparative RH map of the telomeric end of bovine chromosome 2 with human chromosomes 1 and 2. Academic Article uri icon

abstract

  • High density livestock to human comparative maps are necessary for the implementation of comparative positional candidate gene cloning. We have constructed a high-density comparative radiation hybrid (RH) map of the telomeric end of bovine chromosome 2 (BTA2) using a 12,000-rad whole genome cattle-hamster radiation hybrid (WGRH) panel. Eighteen bovine EST markers with orthologues on human chromosomes 1 and 2 (HSA1 and HSA2), together with nine microsatellite markers, were typed against the 180 cell lines of the WGRH panel. Twenty-one markers were included in the multi-point framework map at LOD =3.0. The comparative analysis reveals a new segment of highly conserved synteny between HSA2 and BTA2.

published proceedings

  • Cytogenet Genome Res

author list (cited authors)

  • Liu, Z., Womack, J. E., & Antoniou, E.

citation count

  • 1

complete list of authors

  • Liu, Z||Womack, JE||Antoniou, E

publication date

  • January 2003