A high-resolution comparative RH map of the telomeric end of bovine chromosome 2 with human chromosomes 1 and 2. Academic Article

abstract

• High density livestock to human comparative maps are necessary for the implementation of comparative positional candidate gene cloning. We have constructed a high-density comparative radiation hybrid (RH) map of the telomeric end of bovine chromosome 2 (BTA2) using a 12,000-rad whole genome cattle-hamster radiation hybrid (WGRH) panel. Eighteen bovine EST markers with orthologues on human chromosomes 1 and 2 (HSA1 and HSA2), together with nine microsatellite markers, were typed against the 180 cell lines of the WGRH panel. Twenty-one markers were included in the multi-point framework map at LOD =3.0. The comparative analysis reveals a new segment of highly conserved synteny between HSA2 and BTA2.

authors

• Womack, James

published proceedings

• Cytogenet Genome Res

author list (cited authors)

• Liu, Z., Womack, J. E., & Antoniou, E.

citation count

• 1

complete list of authors

• Liu, Z||Womack, JE||Antoniou, E

publication date

• December 2003

publisher

• Karger Publishers  Publisher

keywords

• Animals
• Cattle
• Chromosomes, Human, Pair 1
• Chromosomes, Human, Pair 2
• Chromosomes, Mammalian
• Cricetinae
• Humans
• Mice
• Microsatellite Repeats
• Radiation Hybrid Mapping
• Synteny
• Telomere

Digital Object Identifier (DOI)

• 10.1159/000076295

start page

• 89

end page

• 93

volume

• 103

issue

• 1-2

URL

• http://dx.doi.org/10.1159/000076295