A microfluidic device for investigating concentration-dependent interaction between signals on bacterial biofilm formation
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In this paper, we report the development of a microfluidic model for investigating bacterial biofilm formation and organization in response to different quorum sensing molecules such as autoinducer-2 and indole. A key feature of the proposed model is that the gradient concentration of QS molecules are generated in each chamber without any mixing. This model can be used for developing a fundamental understanding of events leading to bacterial attachment to surfaces that are important in infections. 2009 CBMS.