Novel high-throughput screening system for cancer therapy with simultaneous combination treatments Conference Paper uri icon


  • In this paper, we report the development of a microfluidic high-throughput screening system for high-throughput screening of drug molecule interactions on cancer cell death. A key feature is that 64 pair-wise concentrations (between eight concentrations of two drugs) are generated using a traditional diffusive microfluidic mixer and a time-dependent variable concentration mixer. Using this novel high-throughput combination array, we generated pair-wise combinations of the cancer drug sensitizer doxorubicin and the cytokine TRAIL, and used it for on-chip screening against PC3 prostate cancer cells. Our results identify a concentration range where doxorubicin and TRAIL are synergistic and demonstrates the utility of the system as a high-throughput anti-cancer drug screening tool.

published proceedings

  • 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

author list (cited authors)

  • Kim, J. Y., Taylor, D., Rege, K., Kim, H. S., Han, A. R., & Jayaraman, A.

complete list of authors

  • Kim, JY||Taylor, D||Rege, K||Kim, HS||Han, AR||Jayaraman, A

publication date

  • December 2010