A HIGH-THROUGHPUT FULLY-AUTOMATED MICROFLUIDIC LIVE CELL ARRAY FOR COMBINATION DRUG TREATMENT ANALYSIS OF COLORECTAL CANCER CELLS Conference Paper

abstract

• Combination chemotherapies play an important role in clinical cancer treatment. We have previously developed a microfluidic high-throughput drug screening platform and used it for the screening of prostate cancer sensitizing agents. We have further developed the system into a fully automated live cell array platform with uniform cell seeding for better control, and used the platform to investigate the gene expression regulation of colorectal cancer cells in response to combination cancer drug treatment. The results showed significant drug effects on the proliferation of the HCT116 colorectal cancer cells, demonstrating the potential of this microfluidic device as a high-throughput combination chemotherapeutic drug-screening platform. 2011 IEEE.

name of conference

• 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference

authors

• Han, Arum
• Jayaraman, Arul

published proceedings

• 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference

author list (cited authors)

• Wang, H., Kim, J., Jayaraman, A., Cypert, M., Hua, J., Bittner, M., & Han, A.

citation count

• 0

complete list of authors

• Wang, H||Kim, J||Jayaraman, A||Cypert, M||Hua, J||Bittner, M||Han, A

publication date

• January 2011

publisher

• Institute of Electrical and Electronics Engineers (IEEE)  Publisher

keywords

• 5 Development Of Treatments And Therapeutic Interventions
• 5.1 Pharmaceuticals
• Bioengineering
• Biotechnology
• Cancer
• Colo-rectal Cancer
• Digestive Diseases
• Prostate Cancer
• Urologic Diseases

Digital Object Identifier (DOI)

• 10.1109/transducers.2011.5969335

International Standard Book Number (ISBN) 13

• 9781457701573

start page

• 2148

end page

• 2151

URL

• http://dx.doi.org/10.1109/transducers.2011.5969335