Uterine biology in pigs and sheep Academic Article uri icon


  • There is a dialogue between the developing conceptus (embryo-fetus and associated placental membranes) and maternal uterus which must be established during the peri-implantation period for pregnancy recognition signaling, implantation, regulation of gene expression by uterine epithelial and stromal cells, placentation and exchange of nutrients and gases. The uterus provide a microenvironment in which molecules secreted by uterine epithelia or transported into the uterine lumen represent histotroph required for growth and development of the conceptus and receptivity of the uterus to implantation. Pregnancy recognition signaling mechanisms sustain the functional lifespan of the corpora lutea (CL) which produce progesterone, the hormone of pregnancy essential for uterine functions that support implantation and placentation required for a successful outcome of pregnancy. It is within the peri-implantation period that most embryonic deaths occur due to deficiencies attributed to uterine functions or failure of the conceptus to develop appropriately, signal pregnancy recognition and/or undergo implantation and placentation. With proper placentation, the fetal fluids and fetal membranes each have unique functions to ensure hematotrophic and histotrophic nutrition in support of growth and development of the fetus. The endocrine status of the pregnant female and her nutritional status are critical for successful establishment and maintenance of pregnancy. This review addresses the complexity of key mechanisms that are characteristic of successful reproduction in sheep and pigs and gaps in knowledge that must be the subject of research in order to enhance fertility and reproductive health of livestock species. 2012 Bazer et al.; licensee BioMed Central Ltd.

published proceedings

  • Journal of Animal Science and Biotechnology

author list (cited authors)

  • Bazer, F. W., Song, G., Kim, J., Dunlap, K. A., Satterfield, M. C., Johnson, G. A., Burghardt, R. C., & Wu, G.

complete list of authors

  • Bazer, FW||Song, G||Kim, J||Dunlap, KA||Satterfield, MC||Johnson, GA||Burghardt, RC||Wu, G

publication date

  • July 2012