Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis Academic Article uri icon

abstract

  • Azole drugs such as econazole, are active on Mycobacterium tuberculosis and Mycobacterium smegmatis ; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmpL5-mmpS5 conferred resistance to econazole in M. tuberculosis . We herein report that an azole-resistant mutant screen in M. smegmatis rendered mutations in rshA, encoding a non-essential anti-sigma H protein.

author list (cited authors)

  • Morbidoni, H. R., de la Iglesia, A. I., Figueroa, V., Di Capua, C., Ioerger, T. R., & Parish, T.

publication date

  • January 1, 2019 11:11 AM