Benefit of screening mammography in reducing the rate of late-stage breast cancer diagnoses (United States). Academic Article uri icon

abstract

  • OBJECTIVE: We studied the benefit of modern mammography screening in community settings, evaluating age-related differences in rates of late-stage breast cancer detection. METHODS: Our multicenter population-based case-control study included 931 black and white women with incident breast cancer (American Joint Commission on Cancer Stage IIB or higher) diagnosed 1994-1998 and 4,016 randomly sampled controls never diagnosed with breast cancer. Adjusted odds ratios (ORs) estimated the relative rate of late-stage diagnosis in screened and non-screened women. RESULTS: Women aged 50-64 at diagnosis with at least one screening mammogram in the previous 2 years were significantly less likely to have late-stage diagnosis (OR = 0.41, 95% CI 0.33-0.52). Results for women aged 40-49 were consistent with a screening benefit, although the confidence interval marginally overlapped the null (OR = 0.81, 95% CI 0.64-1.02). Mammography screening was associated with lower rates of late-stage breast cancer among both premenopausal (OR = 0.64, 95% CI 0.50-0.81) and postmenopausal (OR = 0.44, 95% CI 0.35-0.56) women. CONCLUSIONS: With modern mammography in the community, rates of late-stage breast cancer diagnoses are lower in screened compared to non-screened women ages 40 and older, but age-related differences persist.

published proceedings

  • Cancer Causes Control

author list (cited authors)

  • Norman, S. A., Localio, A. R., Zhou, L., Weber, A. L., Coates, R. J., Malone, K. E., ... Nadel, M. R.

citation count

  • 22

complete list of authors

  • Norman, Sandra A||Localio, A Russell||Zhou, Lan||Weber, Anita L||Coates, Ralph J||Malone, Kathleen E||Bernstein, Leslie||Marchbanks, Polly A||Liff, Jonathan M||Lee, Nancy C||Nadel, Marion R

publication date

  • September 2006