Total Syntheses of Vancomycin Academic Article uri icon


  • A total synthesis of the vancomycin aglycon 1 has eluded synthetic chemists for so many years that the preparation of this molecule has become a vendetta for some groups. Finally, and almost simultaneously, research teams led by Evans and by Nicolaou have succeeded. Similarities and differences in their synthetic approaches are highlighted herein.

altmetric score

  • 8.76

author list (cited authors)

  • Zhang, A. J., & Burgess, K.

citation count

  • 20

publication date

  • March 1999