A Linker Scaffold to Present Dimers of Pharmacophores Prepared by Solid‐Phase Syntheses Academic Article uri icon

abstract

  • Mimicry or disruption of protein-protein interactions requires the presentation of pharmacophores to match discontinuous sites on the macromolecular surfaces. The linker shown here was designed to achieve this. The orthogonal protecting groups on the linker allow it to be differentially functionalized, then cleaved from the resin using re-agents that will not interfere with biological assays. Fmoc-9-fluorenylmethoxycarbonyl, Boc = tert-butoxycarbonyl.

altmetric score

  • 3

author list (cited authors)

  • Pattarawarapan, M., & Burgess, K.

citation count

  • 12

publication date

  • December 2000

publisher