Chiral 1,3-cyclobutane amino acids: Syntheses and extended conformations
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abstract
Optically active samples of the N-protected 1,3-cyclobutane amino acids 1 and 2 were prepared from -pinene. The synthesis of 1 is enantiodivergent insofar as both optical antipodes of the product can be prepared from the same -pinene enantiomer. Single crystal X-ray diffraction studies of derivatives of 1 reveal these compounds can have extended conformations.