Chiral 1,3-cyclobutane amino acids: Syntheses and extended conformations
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Optically active samples of the N-protected 1,3-cyclobutane amino acids 1 and 2 were prepared from α-pinene. The synthesis of 1 is enantiodivergent insofar as both optical antipodes of the product can be prepared from the same α-pinene enantiomer. Single crystal X-ray diffraction studies of derivatives of 1 reveal these compounds can have extended conformations.
author list (cited authors)
Burgess, K., Li, S., & Rebenspies, J.