A method for removal of N-BOC protecting groups from substrates on TFA-sensitive resins Academic Article uri icon


  • N-Tert-butyloxycarbonyl groups can be removed from substrates supported on Rink's amide resin by treatment with trimethylsilyl triflate/2,6-lutidine. This methodology was illustrated here with syntheses of several peptides, but it is likely to be used more extensively in solid phase syntheses of small molecule libraries.

author list (cited authors)

  • Zhang, A. J., Russell, D. H., zhu, J., & Burgess, K.

citation count

  • 53

publication date

  • October 1998