A method for removal of N-BOC protecting groups from substrates on TFA-sensitive resins Academic Article

abstract

• N-Tert-butyloxycarbonyl groups can be removed from substrates supported on Rink's amide resin by treatment with trimethylsilyl triflate/2,6-lutidine. This methodology was illustrated here with syntheses of several peptides, but it is likely to be used more extensively in solid phase syntheses of small molecule libraries.

authors

• Burgess, Kevin
• Russell, David

published proceedings

• TETRAHEDRON LETTERS

altmetric score

• 3

author list (cited authors)

• Zhang, A. J., Russell, D. H., Zhu, J. P., & Burgess, K.

citation count

• 51

complete list of authors

• Zhang, AJ||Russell, DH||Zhu, JP||Burgess, K

publication date

• October 1998

publisher

• Elsevier  Publisher

published in

• Tetrahedron Letters  Journal

keywords

• N-protection
• Solid Phase Syntheses
• Tert-butyloxycarbonyl

Digital Object Identifier (DOI)

• 10.1016/S0040-4039(98)01631-1

start page

• 7439

end page

• 7442

volume

• 39

issue

• 41

URL

• http://dx.doi.org/10.1016/s0040-4039(98)01631-1