PRACTICAL ASYMMETRIC SYNTHESES OF ALL 4 2,3-METHANOLEUCINE STEREOISOMERS Academic Article

abstract

• All four stereoisomers of the 2,3-methanoamino acids BOC-E-cyclo-Leu and BOC-Z-cyclo-Leu were prepared from the optically active diol 4 (and its enantiomer) derived from valine. The challenges associated with introducing protected amine functionalities cis to the side chain were overcome by using the vinylogous malonate synthon, dimethyl gluconate. 1995.

authors

• Burgess, Kevin

published proceedings

• TETRAHEDRON LETTERS

altmetric score

• 3

author list (cited authors)

• BURGESS, K., & LI, W.

citation count

• 26

complete list of authors

• BURGESS, K||LI, W

publication date

• April 1995

publisher

• Elsevier  Publisher

published in

• Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry  Journal

keywords

• Amino Acid
• Conformationally Constrained
• Cyclopropane

Digital Object Identifier (DOI)

• 10.1016/0040-4039(95)00382-M

start page

• 2725

end page

• 2728

volume

• 36

issue

• 16

URL

• http://dx.doi.org/10.1016/0040-4039(95)00382-m