PRACTICAL ASYMMETRIC SYNTHESES OF ALL 4 2,3-METHANOLEUCINE STEREOISOMERS
- Additional Document Info
- View All
All four stereoisomers of the 2,3-methanoamino acids BOC-E-cyclo-Leu and BOC-Z-cyclo-Leu were prepared from the optically active diol 4 (and its enantiomer) derived from valine. The challenges associated with introducing protected amine functionalities cis to the side chain were overcome by using the vinylogous malonate synthon, dimethyl gluconate. 1995.
author list (cited authors)
complete list of authors