Practical asymmetric syntheses of all four 2,3-methanoleucine stereoisomers Academic Article uri icon


  • All four stereoisomers of the 2,3-methanoamino acids BOC-E-cyclo-Leu and BOC-Z-cyclo-Leu were prepared from the optically active diol 4 (and its enantiomer) derived from valine. The challenges associated with introducing protected amine functionalities cis to the side chain were overcome by using the vinylogous malonate synthon, dimethyl gluconate. © 1995.

altmetric score

  • 3

author list (cited authors)

  • Burgess, K., & Li, W.

citation count

  • 20

publication date

  • April 1995