Fluorinated and iodinated templates for syntheses of beta-turn peptidomimetics Academic Article uri icon

abstract

  • Various 2-fluoro-5-nitrobenzoic acids and the homocysteine derivative 2 have been combined in solid phase syntheses of the peptidomimetic types 3-6. NMR and CD data collected for some of these compounds indicate that a transannular SO to HN hydrogen bond stabilizes -turn conformations for the sulfones and one of the sulfoxide epimers. An extensive library of compounds was made and studied to test this assertion. 2002 Elsevier Science Ltd. All rights reserved.

published proceedings

  • TETRAHEDRON

author list (cited authors)

  • Jiang, L., & Burgess, K.

citation count

  • 5

complete list of authors

  • Jiang, L||Burgess, K

publication date

  • October 2002