Iridium catalyzed enantioselective hydrogenation of alpha-alkoxy and beta-alkoxy vinyl ethers Academic Article

abstract

• Iridium catalyzed, enantioselective hydrogenations of functionalized, acid-sensitive vinyl ethers are reported. These reactions are mediated by the chiral N-carbene-oxazoline complex 1 that, unlike similar N,P-ligated catalysts (6 and 7), gives hydrogenation products (with enantioselectivities up to 96%) without significant acid-mediated degradation. In general, higher enantioselectivities were observed for the allylic alcohol derivatives (2) than the -methoxycinnamate-based compounds (4). 2012 The Royal Society of Chemistry.

authors

• Burgess, Kevin

published proceedings

• RSC ADVANCES

author list (cited authors)

• Zhu, Y. e., & Burgess, K.

citation count

• 16

complete list of authors

• Zhu, Ye||Burgess, Kevin

publication date

• June 2012

publisher

• Royal Society of Chemistry (RSC)  Publisher

keywords

• 34 Chemical Sciences
• 3402 Inorganic Chemistry
• 3405 Organic Chemistry

Digital Object Identifier (DOI)

• 10.1039/c2ra01350a

start page

• 4728

end page

• 4735

volume

• 2

issue

• 11

URL

• http://dx.doi.org/10.1039/c2ra01350a