2,3-methanoamino acid analogs of Arg stabilize secondary structures of a 13 amino acid peptide in aqueous solution
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abstract
Peptidomimetics 1 and 2 of RN24 (an RNase A C-peptide analog) in which the ArgMO residue is replaced by 2R.3Scyclo-Arg and by 2S,3S-cyclo-Arg, respectively, show less temperature dependence in CD studies than the parent peptide.