The importance of phosphine-to-rhodium ratios in enantioselective hydroborations
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Catalyzed hydroborations of several 1,1-disubstituted aryl alkenes were studied. Formation of tertiary alcohols (after oxidation) was favored when high phosphine-to-rhodium ratios were used. Enantioselective variants of this process can give chiral primary and tertiary alcohols with different enantioselectivities indicative of mechanistic differences. Measurements of product optical yields as a function of optical purities of the catalyst gave a linear correlation. The mechanistic implications of these data are discussed. © 1994.
author list (cited authors)
Burgess, K., & van der Donk, W. A.