Synthesis of an oxyamide linked nucleotide dimer and incorporation into antisense oligonucleotide sequences Academic Article uri icon


  • Two derivatives of thymidine, a 5′-protected 3′-hydroxylamine and 5′-carboxy-3′-protected compound, were prepared and coupled to form an oxyamide-linked dinucleotide analogue; this dimer was incorporated into an oligodeoxynucleotide then shown to anneal to complementary DNA with nearly the same affinity as the natural sequence.

altmetric score

  • 6

author list (cited authors)

  • Burgess, K., Gibbs, R. A., Metzker, M. L., & Raghavachari, R.

citation count

  • 20

publication date

  • January 1994