Synthesis of an oxyamide linked nucleotide dimer and incorporation into antisense oligonucleotide sequences
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Two derivatives of thymidine, a 5′-protected 3′-hydroxylamine and 5′-carboxy-3′-protected compound, were prepared and coupled to form an oxyamide-linked dinucleotide analogue; this dimer was incorporated into an oligodeoxynucleotide then shown to anneal to complementary DNA with nearly the same affinity as the natural sequence.
author list (cited authors)
Burgess, K., Gibbs, R. A., Metzker, M. L., & Raghavachari, R.