SYNTHESIS OF AN OXYAMIDE LINKED NUCLEOTIDE DIMER AND INCORPORATION INTO ANTISENSE OLIGONUCLEOTIDE SEQUENCES Academic Article uri icon

abstract

  • Two derivatives of thymidine, a 5-protected 3-hydroxylamine and 5-carboxy-3-protected compound, were prepared and coupled to form an oxyamide-linked dinucleotide analogue; this dimer was incorporated into an oligodeoxynucleotide then shown to anneal to complementary DNA with nearly the same affinity as the natural sequence.

published proceedings

  • JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS

altmetric score

  • 6

author list (cited authors)

  • BURGESS, K., GIBBS, R. A., METZKER, M. L., & RAGHAVACHARI, R.

citation count

  • 24

complete list of authors

  • BURGESS, K||GIBBS, RA||METZKER, ML||RAGHAVACHARI, R

publication date

  • January 1994