As the size of contacting and sliding tribosystems decrease, intermolecular or adhesive forces become significant partly due to nanometer size surface roughness. The presence of adhesion has a major influence on the interfacial contact and friction forces as well as the microtribosystem dynamics and thus influences the overall dynamic friction behavior. In this paper, a dynamic friction model that explicitly includes adhesion, interfacial damping and the system dynamics for realistic rough surfaces was developed. The results show that the amplitude and mean value of the time varying normal contact and friction forces increase in the presence of adhesion under continuous contact conditions. Also, due to the attractive nature of adhesion, its presence delays or eliminates the occurrence of loss of contact. Furthermore, in the presence of significant adhesion, dynamic friction behavior is significantly more complicated compared to the no adhesion case, and the dynamic friction coefficient predictions may be misleading. Thus, it is more appropriate to discuss dynamic friction force instead of dynamic friction coefficient under dynamic conditions.