miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer. Academic Article uri icon


  • Genomic amplification of 3q26.2 locus leads to theincreased expression of microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC). Our results demonstrate that miR551b-3p translocates to the nucleus with the aid of importin-8 (IPO8) and activates STAT3 transcription. As a consequence, miR551b upregulates the expression of oncostatin M receptor (OSMR) and interleukin-31 receptor- (IL-31RA) as well as their ligands OSM and IL-31 through STAT3 transcription. We defined this set of genes induced by miR551b-3p as the "oncostatin signaling module," which provides oncogenic addictions in cancer cells. Notably, OSM is highly expressed in TNBC, and the elevated expression of OSM associates with poor outcome in estrogen-receptor-negative breast cancer patients. Conversely, targeting miR551b with anti-miR551b-3p reduced the expression of the OSM signaling module and reduced tumor growth, as well as migration and invasion of breast cancer cells.

published proceedings

  • Cell Rep

altmetric score

  • 15.75

author list (cited authors)

  • Parashar, D., Geethadevi, A., Aure, M. R., Mishra, J., George, J., Chen, C., ... Chaluvally-Raghavan, P.

citation count

  • 46

complete list of authors

  • Parashar, Deepak||Geethadevi, Anjali||Aure, Miriam Ragle||Mishra, Jyotsna||George, Jasmine||Chen, Changliang||Mishra, Manoj K||Tahiri, Andliena||Zhao, Wei||Nair, Bindu||Lu, Yiling||Mangala, Lingegowda S||Rodriguez-Aguayo, Cristian||Lopez-Berestein, Gabriel||Camara, Amadou KS||Liang, Mingyu||Rader, Janet S||Ramchandran, Ramani||You, Ming||Sood, Anil K||Kristensen, Vessela N||Mills, Gordon B||Pradeep, Sunila||Chaluvally-Raghavan, Pradeep

publication date

  • January 2019