Coherent Raman protocol of biosensing with a hollow photonic-crystal fiber
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abstract
A nonlinear-optical protocol of biosensing is demonstrated with a hollow-core photonic-crystal fiber. This protocol involves phase-matched four-wave mixing of millijoule nanosecond laser pulses guided by photonic band gaps of hollow fibers with a two-dimensionally periodic cladding and a core diameter of about 50 m. Raman resonances related to the stretching vibrations of water molecules inside the hollow fiber core are detected in the spectrum of the four-wave mixing signal, suggesting phase-matched coherent anti-Stokes Raman scattering in hollow photonic-crystal fibers as a convenient sensing technique for condensed-phase biospecies adsorbed on the inner fiber walls and trace gas detection, including exhale-gas diagnostics. 2005-IOS Press and the authors. All rights reserved.