Optical Control of CRAC Channels Using Photoswitchable Azopyrazoles. Academic Article uri icon

abstract

  • The Ca2+ release-activated Ca2+ (CRAC) channels control many Ca2+-modulated physiological processes in mammals. Hyperactivating CRAC channels are known to cause several human diseases, including Stormorken syndrome. Here, we show the design of azopyrazole-derived photoswitchable CRAC channel inhibitors (designated piCRACs), which enable optical inhibition of store-operated Ca2+ influx and downstream signaling. Moreover, piCRAC-1 has been applied in vivo to alleviate thrombocytopenia and hemorrhage in a zebrafish model of Stormorken syndrome in a light-dependent manner.

published proceedings

  • J Am Chem Soc

altmetric score

  • 4.35

author list (cited authors)

  • Yang, X., Ma, G., Zheng, S., Qin, X., Li, X., Du, L., ... Li, M

citation count

  • 16

complete list of authors

  • Yang, Xingye||Ma, Guolin||Zheng, Sisi||Qin, Xiaojun||Li, Xiang||Du, Lupei||Wang, Youjun||Zhou, Yubin||Li, Minyong

publication date

  • April 2020