Unconventional Secondary Structure Mimics: Ladder-Rungs. Academic Article uri icon


  • Secondary structures tend to be recognizable because they have repeating structural motifs, but mimicry of these does not have to follow such well-defined patterns. Bioinformatics studies to match side-chain orientations of a novel hydantoin triazole chemotype (1) to protein-protein interfaces revealed it tends to align well across parallel and antiparallel sheets, like rungs on a ladder. One set of these overlays was observed for the protein-protein interaction uPAuPAR. Consequently, chemotype 1 was made with appropriate side-chains to mimic uPA at this interface. Biophysical assays indicate these compounds did in fact bind uPAR, and elicit cellular responses that affected invasion, migration, and wound healing.

published proceedings

  • Angew Chem Int Ed Engl

altmetric score

  • 0.75

author list (cited authors)

  • Lin, C., Arancillo, M., Whisenant, J., & Burgess, K.

citation count

  • 9

complete list of authors

  • Lin, Chen-Ming||Arancillo, Maritess||Whisenant, Jonathan||Burgess, Kevin

publication date

  • June 2020