Stepwise Assembly of Turn-on Fluorescence Sensors in Multicomponent Metal-Organic Frameworks for inVitro Cyanide Detection. Academic Article uri icon

abstract

  • The controlled synthesis of multicomponent metal-organic frameworks (MOFs) allows for the precise placement of multiple cooperative functional groups within a framework, leading to emergent synergistic effects. Herein, we demonstrate that turn-on fluorescence sensors can be assembled by combining a fluorophore and a recognition moiety within a complex cavity of a multicomponent MOF. An anthracene-based fluorescent linker and a hemicyanine-containing CN- -responsive linker were sequentially installed into the lattice of PCN-700. The selective binding of CN- to hemicyanine inhibited the energy transfer between the two moieties, resulting in a fluorescence turn-on effect. Taking advantage of the high tunability of the MOF platform, the ratio between anthracene and the hemicyanine moiety could be fine-tuned in order to maximize the sensitivity of the overall framework. The optimized MOF-sensor had a CN- -detection limit of 0.05m, which is much lower than traditional CN- fluorescent sensors (about 0.2m).

published proceedings

  • Angew Chem Int Ed Engl

altmetric score

  • 2.1

author list (cited authors)

  • Li, J., Yuan, S., Qin, J., Pang, J., Zhang, P., Zhang, Y., ... Zhou, H.

citation count

  • 79

complete list of authors

  • Li, Jialuo||Yuan, Shuai||Qin, Jun-Sheng||Pang, Jiandong||Zhang, Peng||Zhang, Yingmu||Huang, Yanyan||Drake, Hannah F||Liu, Wenshe R||Zhou, Hong-Cai

publication date

  • June 2020

publisher