Lipoprotein Lipase Sorting: Sphingomyelin and a Proteoglycan Show the Way
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A mechanistic description for how soluble protein cargos are sorted into distinct vesicle classes at the level of the trans-Golgi network (TGN) has remained elusive. In a recent study in Developmental Cell, Sundberg et al. reveal that sphingomyelin and a proteoglycan mediate lipoprotein lipase sorting in the TGN.
author list (cited authors)
Bankaitis, V. A., & Wang, Y.