Prefrontal cortex projections to the nucleus reuniens suppress freezing following two-way signaled avoidance training. Academic Article

abstract

• Signaled active avoidance (SAA) behavior requires the suppression of defensive reactions, such as freezing, that conflict with the avoidance response. The neural mechanisms of this inhibitory process are not well understood. Here, we demonstrate that ventromedial prefrontal cortex projections to the nucleus reuniens of the thalamus are recruited following SAA training to suppress freezing in rats. This projection may serve as a crucial common pathway for the inhibition of innate defensive reactions that interfere with proactive behavior, thus facilitating adaptive coping.

authors

• Moscarello, Justin

published proceedings

• Learn Mem

altmetric score

• 8.2

author list (cited authors)

• Moscarello, J. M.

citation count

• 8

complete list of authors

• Moscarello, Justin M

publication date

• March 2020

publisher

• Cold Spring Harbor Laboratory  Publisher

published in

• Learning and Memory  Journal

keywords

• Animals
• Avoidance Learning
• Conditioning, Classical
• Conflict, Psychological
• Freezing Reaction, Cataleptic
• Inhibition, Psychological
• Midline Thalamic Nuclei
• Prefrontal Cortex
• Rats

PubMed Central ID

• 32071258

Digital Object Identifier (DOI)

• 10.1101/lm.050377.119

start page

• 119

end page

• 123

volume

• 27

issue

• 3

URL

• http://dx.doi.org/10.1101/lm.050377.119