Healing efficacy of fracture-targeted GSK3 inhibitor-loaded micelles for improved fracture repair. Academic Article uri icon

abstract

  • AIM: To evaluate the fracture healing capabilities of a GSK3 inhibitor, 6-bromoindirubin-3'-oxime, coupled with an aspartic acid octapeptide in a micellar delivery system. MATERIALS & METHODS: The efficacy of the intravenously administered micelles to accelerate healing of femoral fracture in mice was evaluated. Micro-computed tomography analysis was employed to obtain bone density, total volume, relative volume, trabecular thickness and trabecular spacing. RESULTS: Both fracture bone mineral density and volume were significantly higher in the micelle treatment groups when compared with controls. The fracture-targeted micelle demonstrates fracture-specific bone anabolism and biocompatibility in off-target tissues. CONCLUSION: Accelerated fracture healing in mice was achieved by targeting the GSK3 inhibitor, 6-bromoindirubin-3'-oxime, to the fracture site.

published proceedings

  • Nanomedicine (Lond)

author list (cited authors)

  • Low, S. A., Galliford, C. V., Jones-Hall, Y. L., Roy, J., Yang, J., Low, P. S., & Kopeek, J.

complete list of authors

  • Low, Stewart A||Galliford, Chris V||Jones-Hall, Yava L||Roy, Jyoti||Yang, Jiyuan||Low, Philip S||Kopeček, Jindřich

publication date

  • January 1, 2017 11:11 AM