Healing efficacy of fracture-targeted GSK3 inhibitor-loaded micelles for improved fracture repair.

abstract

• AIM: To evaluate the fracture healing capabilities of a GSK3 inhibitor, 6-bromoindirubin-3'-oxime, coupled with an aspartic acid octapeptide in a micellar delivery system. MATERIALS & METHODS: The efficacy of the intravenously administered micelles to accelerate healing of femoral fracture in mice was evaluated. Micro-computed tomography analysis was employed to obtain bone density, total volume, relative volume, trabecular thickness and trabecular spacing. RESULTS: Both fracture bone mineral density and volume were significantly higher in the micelle treatment groups when compared with controls. The fracture-targeted micelle demonstrates fracture-specific bone anabolism and biocompatibility in off-target tissues. CONCLUSION: Accelerated fracture healing in mice was achieved by targeting the GSK3 inhibitor, 6-bromoindirubin-3'-oxime, to the fracture site.

authors

• Jones-Hall, Yava

published proceedings

• Nanomedicine (Lond)

altmetric score

• 5.256

author list (cited authors)

• Low, S. A., Galliford, C. V., Jones-Hall, Y. L., Roy, J., Yang, J., Low, P. S., & Kopeek, J.

citation count

• 9

complete list of authors

• Low, Stewart A||Galliford, Chris V||Jones-Hall, Yava L||Roy, Jyoti||Yang, Jiyuan||Low, Philip S||Kopeček, Jindřich

publication date

• February 2017

publisher

• Future Science Group  Publisher

published in

• Nanomedicine  Journal

keywords

• Animals
• Bone Density
• Bone Targeting
• Drug Delivery Systems
• Fracture Healing
• Glycogen Synthase Kinase 3 Beta
• Humans
• Indoles
• Male
• Mice
• Micelles
• Molecular Structure
• Molecular Targeted Therapy
• Osteogenesis
• Oximes
• Surface Properties
• Tissue Distribution
• X-ray Microtomography

PubMed Central ID

• 28093944

Digital Object Identifier (DOI)

• 10.2217/nnm-2016-0340

start page

• 185

end page

• 193

volume

• 12

issue

• 3

URL

• http://dx.doi.org/10.2217/nnm-2016-0340