Enhanced antibacterial activity of amino acids-functionalized multi walled carbon nanotubes by a simple method. Academic Article uri icon


  • Multi-walled carbon nanotubes (MWCNTs) were first functionalized by arginine and lysine under microwave radiation. Surface functionalization was confirmed by Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, and transmission electron microscopy (TEM). After the MWCNTs were functionalized by arginine and lysine, the antibacterial activity of all treated samples was increased significantly against all bacteria that were tested. Based on the observed minimum inhibitory concentration and radial diffusion assay, the sequence of antibacterial activity was MWCNTs-arginine>MWCNTs-lysine>pristine MWCNTs. The functionalized MWCNTs were especially effective against gram-negative bacteria (e.g., Escherichia coli and Salmonella typhimurium). Interestingly, the MWCNT samples were effective against the resistant strain Staphylococcos aureus. The enhanced antibacterial activity was attributed to electrostatic adsorption of bacteria membrane due to positive charges of the functional groups on MWCNTs surface. Since MWCNTs have lower cytotoxicity than single-walled carbon nanotubes, their functionalization with cationic amino acids could be a beneficial approach in the disinfection industry.

published proceedings

  • Colloids Surf B Biointerfaces

author list (cited authors)

  • Zardini, H. Z., Amiri, A., Shanbedi, M., Maghrebi, M., & Baniadam, M.

citation count

  • 151

complete list of authors

  • Zardini, Hadi Zare||Amiri, Ahmad||Shanbedi, Mehdi||Maghrebi, Morteza||Baniadam, Majid

publication date

  • April 2012